Simple and efficient method for aromatization of tetrahydro-β-carbolines by using K2S2O8 as a catalyst and its antimicrobial activity comparison with molecular docking studies
- Авторлар: Kurumanna A.1, Ashok K.1, Rambabu S.1, Sonyanaik B.1, Ravi D.1, Madhu P.1, Sakram B.1
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Мекемелер:
- Department of Chemistry
- Шығарылым: Том 87, № 11 (2017)
- Беттер: 2703-2711
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221634
- DOI: https://doi.org/10.1134/S1070363217110287
- ID: 221634
Дәйексөз келтіру
Аннотация
A novel and efficient aromatization of tetrahydro-β-carbolines under mild conditions using K2S2O8 as a catalyst was developed. The method is applicable for all kinds of C1 substituted systems. All synthesized compounds were screened for their in vitro antibacterial activity against Staphylococus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia, as well as fungi, such as Aspergillus flavus and Fusarium oxysporum. Compounds 4b, 4g, 4i, and 4k demonstrated excellent in vitro antibacterial and antifungal activities than the standard drugs. The docking studies were carried out for most active compounds 4b, 4g, 4i, and 4k.
Негізгі сөздер
Авторлар туралы
A. Kurumanna
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Tarnaka, Hyderabad, Telangana, 500007
K. Ashok
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Tarnaka, Hyderabad, Telangana, 500007
S. Rambabu
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Tarnaka, Hyderabad, Telangana, 500007
B. Sonyanaik
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Tarnaka, Hyderabad, Telangana, 500007
D. Ravi
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Tarnaka, Hyderabad, Telangana, 500007
P. Madhu
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Tarnaka, Hyderabad, Telangana, 500007
B. Sakram
Department of Chemistry
Хат алмасуға жауапты Автор.
Email: bschemou@gmail.com
Үндістан, Tarnaka, Hyderabad, Telangana, 500007