Simple and efficient method for aromatization of tetrahydro-β-carbolines by using K2S2O8 as a catalyst and its antimicrobial activity comparison with molecular docking studies
- 作者: Kurumanna A.1, Ashok K.1, Rambabu S.1, Sonyanaik B.1, Ravi D.1, Madhu P.1, Sakram B.1
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隶属关系:
- Department of Chemistry
- 期: 卷 87, 编号 11 (2017)
- 页面: 2703-2711
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221634
- DOI: https://doi.org/10.1134/S1070363217110287
- ID: 221634
如何引用文章
详细
A novel and efficient aromatization of tetrahydro-β-carbolines under mild conditions using K2S2O8 as a catalyst was developed. The method is applicable for all kinds of C1 substituted systems. All synthesized compounds were screened for their in vitro antibacterial activity against Staphylococus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia, as well as fungi, such as Aspergillus flavus and Fusarium oxysporum. Compounds 4b, 4g, 4i, and 4k demonstrated excellent in vitro antibacterial and antifungal activities than the standard drugs. The docking studies were carried out for most active compounds 4b, 4g, 4i, and 4k.
作者简介
A. Kurumanna
Department of Chemistry
Email: bschemou@gmail.com
印度, Tarnaka, Hyderabad, Telangana, 500007
K. Ashok
Department of Chemistry
Email: bschemou@gmail.com
印度, Tarnaka, Hyderabad, Telangana, 500007
S. Rambabu
Department of Chemistry
Email: bschemou@gmail.com
印度, Tarnaka, Hyderabad, Telangana, 500007
B. Sonyanaik
Department of Chemistry
Email: bschemou@gmail.com
印度, Tarnaka, Hyderabad, Telangana, 500007
D. Ravi
Department of Chemistry
Email: bschemou@gmail.com
印度, Tarnaka, Hyderabad, Telangana, 500007
P. Madhu
Department of Chemistry
Email: bschemou@gmail.com
印度, Tarnaka, Hyderabad, Telangana, 500007
B. Sakram
Department of Chemistry
编辑信件的主要联系方式.
Email: bschemou@gmail.com
印度, Tarnaka, Hyderabad, Telangana, 500007
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