Synthesis, characterisation, and antibacterial activity of some novel vanillin related hydrazone derivatives bearing 1,2,3-triazole ring
- Авторы: Kiran K.1,2, Ashok D.3, Rao B.3, Sarasija M.1, Rao A.4
-
Учреждения:
- Department of Chemistry
- Green Evolution Laboratories
- Green and Medicinal Chemistry Laboratory, Department of Chemistry
- Vagdevi Innoscience Pvt. Ltd
- Выпуск: Том 87, № 6 (2017)
- Страницы: 1288-1294
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/220374
- DOI: https://doi.org/10.1134/S1070363217060251
- ID: 220374
Цитировать
Аннотация
Vanillin, hydrazone and 1,2,3-triazole containing functional groups derivatives demonstrate antibacterial activity. In the present work, we present synthesis of eight new vanillin related hydrazone derivatives bearing 1,2,3-triazole ring skeleton 9a–9e, 10a–10e obtained with high yields by the coupling of aldehydes 6 and 7 with substituted benzohydrazides 8a–8e in ethanol. IR, NMR and MS data and elemental analysis confirm the structures of products. All title compounds were evaluated in vitro for their antibacterial activity against a panel of Gram positive and Gram negative bacteria and compounds 9d and 10d exhibited high activity.
Ключевые слова
Об авторах
K. Kiran
Department of Chemistry; Green Evolution Laboratories
Email: ashokdou@gmail.com
Индия, Hyderabad, Telangana, 500085; Nalgonda, Telangana, 00085
D. Ashok
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Автор, ответственный за переписку.
Email: ashokdou@gmail.com
Индия, Hyderabad, Telangana, 500085
B. Rao
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: ashokdou@gmail.com
Индия, Hyderabad, Telangana, 500085
M. Sarasija
Department of Chemistry
Email: ashokdou@gmail.com
Индия, Karimnagar, Telangana, 505001
A. Rao
Vagdevi Innoscience Pvt. Ltd
Email: ashokdou@gmail.com
Индия, Nacharam, Hyderabad, Telangana, 500085