Synthesis, characterisation, and antibacterial activity of some novel vanillin related hydrazone derivatives bearing 1,2,3-triazole ring
- Autores: Kiran K.1,2, Ashok D.3, Rao B.3, Sarasija M.1, Rao A.4
-
Afiliações:
- Department of Chemistry
- Green Evolution Laboratories
- Green and Medicinal Chemistry Laboratory, Department of Chemistry
- Vagdevi Innoscience Pvt. Ltd
- Edição: Volume 87, Nº 6 (2017)
- Páginas: 1288-1294
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/220374
- DOI: https://doi.org/10.1134/S1070363217060251
- ID: 220374
Citar
Resumo
Vanillin, hydrazone and 1,2,3-triazole containing functional groups derivatives demonstrate antibacterial activity. In the present work, we present synthesis of eight new vanillin related hydrazone derivatives bearing 1,2,3-triazole ring skeleton 9a–9e, 10a–10e obtained with high yields by the coupling of aldehydes 6 and 7 with substituted benzohydrazides 8a–8e in ethanol. IR, NMR and MS data and elemental analysis confirm the structures of products. All title compounds were evaluated in vitro for their antibacterial activity against a panel of Gram positive and Gram negative bacteria and compounds 9d and 10d exhibited high activity.
Palavras-chave
Sobre autores
K. Kiran
Department of Chemistry; Green Evolution Laboratories
Email: ashokdou@gmail.com
Índia, Hyderabad, Telangana, 500085; Nalgonda, Telangana, 00085
D. Ashok
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Autor responsável pela correspondência
Email: ashokdou@gmail.com
Índia, Hyderabad, Telangana, 500085
B. Rao
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: ashokdou@gmail.com
Índia, Hyderabad, Telangana, 500085
M. Sarasija
Department of Chemistry
Email: ashokdou@gmail.com
Índia, Karimnagar, Telangana, 505001
A. Rao
Vagdevi Innoscience Pvt. Ltd
Email: ashokdou@gmail.com
Índia, Nacharam, Hyderabad, Telangana, 500085