Synthesis, characterisation, and antibacterial activity of some novel vanillin related hydrazone derivatives bearing 1,2,3-triazole ring
- Authors: Kiran K.1,2, Ashok D.3, Rao B.A.3, Sarasija M.1, Rao A.S.4
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Affiliations:
- Department of Chemistry
- Green Evolution Laboratories
- Green and Medicinal Chemistry Laboratory, Department of Chemistry
- Vagdevi Innoscience Pvt. Ltd
- Issue: Vol 87, No 6 (2017)
- Pages: 1288-1294
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/220374
- DOI: https://doi.org/10.1134/S1070363217060251
- ID: 220374
Cite item
Abstract
Vanillin, hydrazone and 1,2,3-triazole containing functional groups derivatives demonstrate antibacterial activity. In the present work, we present synthesis of eight new vanillin related hydrazone derivatives bearing 1,2,3-triazole ring skeleton 9a–9e, 10a–10e obtained with high yields by the coupling of aldehydes 6 and 7 with substituted benzohydrazides 8a–8e in ethanol. IR, NMR and MS data and elemental analysis confirm the structures of products. All title compounds were evaluated in vitro for their antibacterial activity against a panel of Gram positive and Gram negative bacteria and compounds 9d and 10d exhibited high activity.
Keywords
About the authors
K. Kiran
Department of Chemistry; Green Evolution Laboratories
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500085; Nalgonda, Telangana, 00085
D. Ashok
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Author for correspondence.
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500085
B. A. Rao
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500085
M. Sarasija
Department of Chemistry
Email: ashokdou@gmail.com
India, Karimnagar, Telangana, 505001
A. S. Rao
Vagdevi Innoscience Pvt. Ltd
Email: ashokdou@gmail.com
India, Nacharam, Hyderabad, Telangana, 500085