Enviar artigo por via de e-mail Synthesis of Some New Substituted Thieno[2,3-d]pyrimidine Derivatives as Antimicrobial Agents
- Autores: El-Shehry M.1,2, Hosni H.1, Amr A.3,4, Ibrahim A.4, Fayed A.5,6, Elnaggar D.4
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Afiliações:
- Pesticide Chemistry Department
- Al-Zahrawy University College
- Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration and Development Chair (DEDC)
- Applied Organic Chemistry Department
- Respiratory Therapy Department, College of Medical Rehabilitation Sciences
- National Research Center
- Edição: Volume 89, Nº 7 (2019)
- Páginas: 1528-1534
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223006
- DOI: https://doi.org/10.1134/S1070363219070247
- ID: 223006
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Resumo
A series of thieno-pyrimidine derivatives are synthesized from 5′-amino-2,3′-bithiophene-4′-carboxylate via the corresponding intermediate N-benzoylated carboxamide derivatives. The target compounds are tested for antibacterial and antifungal activity. Some of the synthesized compounds demonstrate potent antibacterial activity with LD50 comparable with the reference drug indomethacin.
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Sobre autores
M. El-Shehry
Pesticide Chemistry Department; Al-Zahrawy University College
Email: aamr@ksu.edu.sa
Egito, Dokki, Cairo, 12622; Karbala
H. Hosni
Pesticide Chemistry Department
Email: aamr@ksu.edu.sa
Egito, Dokki, Cairo, 12622
A. Amr
Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration and Development Chair (DEDC); Applied Organic Chemistry Department
Autor responsável pela correspondência
Email: aamr@ksu.edu.sa
Arábia Saudita, Riyadh, 11451; Dokki, Giza, 12622
A. Ibrahim
Applied Organic Chemistry Department
Email: aamr@ksu.edu.sa
Egito, Dokki, Giza, 12622
Ahmed Fayed
Respiratory Therapy Department, College of Medical Rehabilitation Sciences; National Research Center
Email: aamr@ksu.edu.sa
Arábia Saudita, Madinah Munawara, 22624; Cairo, Dokki, 12622
D. Elnaggar
Applied Organic Chemistry Department
Email: aamr@ksu.edu.sa
Egito, Dokki, Giza, 12622
