Synthesis of Some New Substituted Thieno[2,3-d]pyrimidine Derivatives as Antimicrobial Agents
- Авторлар: El-Shehry M.1,2, Hosni H.1, Amr A.3,4, Ibrahim A.4, Fayed A.5,6, Elnaggar D.4
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Мекемелер:
- Pesticide Chemistry Department
- Al-Zahrawy University College
- Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration and Development Chair (DEDC)
- Applied Organic Chemistry Department
- Respiratory Therapy Department, College of Medical Rehabilitation Sciences
- National Research Center
- Шығарылым: Том 89, № 7 (2019)
- Беттер: 1528-1534
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223006
- DOI: https://doi.org/10.1134/S1070363219070247
- ID: 223006
Дәйексөз келтіру
Аннотация
A series of thieno-pyrimidine derivatives are synthesized from 5′-amino-2,3′-bithiophene-4′-carboxylate via the corresponding intermediate N-benzoylated carboxamide derivatives. The target compounds are tested for antibacterial and antifungal activity. Some of the synthesized compounds demonstrate potent antibacterial activity with LD50 comparable with the reference drug indomethacin.
Негізгі сөздер
Авторлар туралы
M. El-Shehry
Pesticide Chemistry Department; Al-Zahrawy University College
Email: aamr@ksu.edu.sa
Египет, Dokki, Cairo, 12622; Karbala
H. Hosni
Pesticide Chemistry Department
Email: aamr@ksu.edu.sa
Египет, Dokki, Cairo, 12622
A. Amr
Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration and Development Chair (DEDC); Applied Organic Chemistry Department
Хат алмасуға жауапты Автор.
Email: aamr@ksu.edu.sa
Сауд Арабиясы, Riyadh, 11451; Dokki, Giza, 12622
A. Ibrahim
Applied Organic Chemistry Department
Email: aamr@ksu.edu.sa
Египет, Dokki, Giza, 12622
Ahmed Fayed
Respiratory Therapy Department, College of Medical Rehabilitation Sciences; National Research Center
Email: aamr@ksu.edu.sa
Сауд Арабиясы, Madinah Munawara, 22624; Cairo, Dokki, 12622
D. Elnaggar
Applied Organic Chemistry Department
Email: aamr@ksu.edu.sa
Египет, Dokki, Giza, 12622