Synthesis of Some New Substituted Thieno[2,3-d]pyrimidine Derivatives as Antimicrobial Agents
- Authors: El-Shehry M.F.1,2, Hosni H.M.1, Amr A.E.3,4, Ibrahim A.A.4, Fayed A.A.5,6, Elnaggar D.H.4
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Affiliations:
- Pesticide Chemistry Department
- Al-Zahrawy University College
- Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration and Development Chair (DEDC)
- Applied Organic Chemistry Department
- Respiratory Therapy Department, College of Medical Rehabilitation Sciences
- National Research Center
- Issue: Vol 89, No 7 (2019)
- Pages: 1528-1534
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223006
- DOI: https://doi.org/10.1134/S1070363219070247
- ID: 223006
Cite item
Abstract
A series of thieno-pyrimidine derivatives are synthesized from 5′-amino-2,3′-bithiophene-4′-carboxylate via the corresponding intermediate N-benzoylated carboxamide derivatives. The target compounds are tested for antibacterial and antifungal activity. Some of the synthesized compounds demonstrate potent antibacterial activity with LD50 comparable with the reference drug indomethacin.
About the authors
M. F. El-Shehry
Pesticide Chemistry Department; Al-Zahrawy University College
Email: aamr@ksu.edu.sa
Egypt, Dokki, Cairo, 12622; Karbala
H. M. Hosni
Pesticide Chemistry Department
Email: aamr@ksu.edu.sa
Egypt, Dokki, Cairo, 12622
A. E. Amr
Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration and Development Chair (DEDC); Applied Organic Chemistry Department
Author for correspondence.
Email: aamr@ksu.edu.sa
Saudi Arabia, Riyadh, 11451; Dokki, Giza, 12622
A. A. Ibrahim
Applied Organic Chemistry Department
Email: aamr@ksu.edu.sa
Egypt, Dokki, Giza, 12622
Ahmed A. Fayed
Respiratory Therapy Department, College of Medical Rehabilitation Sciences; National Research Center
Email: aamr@ksu.edu.sa
Saudi Arabia, Madinah Munawara, 22624; Cairo, Dokki, 12622
D. H. Elnaggar
Applied Organic Chemistry Department
Email: aamr@ksu.edu.sa
Egypt, Dokki, Giza, 12622