Aurones and Analogues: Promising Heterocyclic Scaffolds for Development of Antioxidant and Antimicrobial Agents
- Autores: Irshad M.1, Ali Q.1, Iram F.2, Ahamad S.2, Saleem M.2, Saadia M.3, Batool M.2, Kanwal A.1, Tabassum S.1
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Afiliações:
- Department of Chemistry, Division of Science and Technology
- Department of Chemistry
- Department of Biochemistry
- Edição: Volume 89, Nº 7 (2019)
- Páginas: 1519-1527
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223004
- DOI: https://doi.org/10.1134/S1070363219070235
- ID: 223004
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Resumo
Synthesis of some new multi-functional analogues of 2′-hydroxy chalcone containing isoxazole and pyrazole functions were synthesized, and their pharmacological activity was tested. Chalcone derivatives were synthesized by the reaction of 2′-hydroxy acetophenone with various substituted benzaldehydes in a basic medium. Aurones were isolated upon treatment with mercuric acetate. Synthesized chalcones and aurones were converted into the corresponding isoxazole and pyrazole derivatives upon their reaction with hydroxylamine hydrochloride or hydrazine hydrate, respectively. Structures of the compounds were confirmed by spectroscopic methods. All synthesized compounds were tested for antioxidant and antibacterial potential. Some of those demonstrated excellent antioxidant activity, and one product was identified as a promising antimicrobial candidate.
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Sobre autores
M. Irshad
Department of Chemistry, Division of Science and Technology
Autor responsável pela correspondência
Email: misbahchatha@hotmail.com
Paquistão, Lahore, 54770
Q. Ali
Department of Chemistry, Division of Science and Technology
Email: misbahchatha@hotmail.com
Paquistão, Lahore, 54770
F. Iram
Department of Chemistry
Email: misbahchatha@hotmail.com
Paquistão, Lahore, 75500
S. Ahamad
Department of Chemistry
Email: misbahchatha@hotmail.com
Paquistão, Lahore, 75500
M. Saleem
Department of Chemistry
Email: misbahchatha@hotmail.com
Paquistão, Dera Ghazi Khan, 32200
M. Saadia
Department of Biochemistry
Email: misbahchatha@hotmail.com
Paquistão, Sargodha, 40100
M. Batool
Department of Chemistry
Email: misbahchatha@hotmail.com
Paquistão, Lahore, 54590
A. Kanwal
Department of Chemistry, Division of Science and Technology
Email: misbahchatha@hotmail.com
Paquistão, Lahore, 54770
S. Tabassum
Department of Chemistry, Division of Science and Technology
Email: misbahchatha@hotmail.com
Paquistão, Lahore, 54770