Aurones and Analogues: Promising Heterocyclic Scaffolds for Development of Antioxidant and Antimicrobial Agents
- Авторлар: Irshad M.1, Ali Q.1, Iram F.2, Ahamad S.2, Saleem M.2, Saadia M.3, Batool M.2, Kanwal A.1, Tabassum S.1
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Мекемелер:
- Department of Chemistry, Division of Science and Technology
- Department of Chemistry
- Department of Biochemistry
- Шығарылым: Том 89, № 7 (2019)
- Беттер: 1519-1527
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223004
- DOI: https://doi.org/10.1134/S1070363219070235
- ID: 223004
Дәйексөз келтіру
Аннотация
Synthesis of some new multi-functional analogues of 2′-hydroxy chalcone containing isoxazole and pyrazole functions were synthesized, and their pharmacological activity was tested. Chalcone derivatives were synthesized by the reaction of 2′-hydroxy acetophenone with various substituted benzaldehydes in a basic medium. Aurones were isolated upon treatment with mercuric acetate. Synthesized chalcones and aurones were converted into the corresponding isoxazole and pyrazole derivatives upon their reaction with hydroxylamine hydrochloride or hydrazine hydrate, respectively. Structures of the compounds were confirmed by spectroscopic methods. All synthesized compounds were tested for antioxidant and antibacterial potential. Some of those demonstrated excellent antioxidant activity, and one product was identified as a promising antimicrobial candidate.
Негізгі сөздер
Авторлар туралы
M. Irshad
Department of Chemistry, Division of Science and Technology
Хат алмасуға жауапты Автор.
Email: misbahchatha@hotmail.com
Пәкістан, Lahore, 54770
Q. Ali
Department of Chemistry, Division of Science and Technology
Email: misbahchatha@hotmail.com
Пәкістан, Lahore, 54770
F. Iram
Department of Chemistry
Email: misbahchatha@hotmail.com
Пәкістан, Lahore, 75500
S. Ahamad
Department of Chemistry
Email: misbahchatha@hotmail.com
Пәкістан, Lahore, 75500
M. Saleem
Department of Chemistry
Email: misbahchatha@hotmail.com
Пәкістан, Dera Ghazi Khan, 32200
M. Saadia
Department of Biochemistry
Email: misbahchatha@hotmail.com
Пәкістан, Sargodha, 40100
M. Batool
Department of Chemistry
Email: misbahchatha@hotmail.com
Пәкістан, Lahore, 54590
A. Kanwal
Department of Chemistry, Division of Science and Technology
Email: misbahchatha@hotmail.com
Пәкістан, Lahore, 54770
S. Tabassum
Department of Chemistry, Division of Science and Technology
Email: misbahchatha@hotmail.com
Пәкістан, Lahore, 54770