Aurones and Analogues: Promising Heterocyclic Scaffolds for Development of Antioxidant and Antimicrobial Agents
- Authors: Irshad M.1, Ali Q.1, Iram F.2, Ahamad S.A.2, Saleem M.2, Saadia M.3, Batool M.2, Kanwal A.1, Tabassum S.1
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Affiliations:
- Department of Chemistry, Division of Science and Technology
- Department of Chemistry
- Department of Biochemistry
- Issue: Vol 89, No 7 (2019)
- Pages: 1519-1527
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223004
- DOI: https://doi.org/10.1134/S1070363219070235
- ID: 223004
Cite item
Abstract
Synthesis of some new multi-functional analogues of 2′-hydroxy chalcone containing isoxazole and pyrazole functions were synthesized, and their pharmacological activity was tested. Chalcone derivatives were synthesized by the reaction of 2′-hydroxy acetophenone with various substituted benzaldehydes in a basic medium. Aurones were isolated upon treatment with mercuric acetate. Synthesized chalcones and aurones were converted into the corresponding isoxazole and pyrazole derivatives upon their reaction with hydroxylamine hydrochloride or hydrazine hydrate, respectively. Structures of the compounds were confirmed by spectroscopic methods. All synthesized compounds were tested for antioxidant and antibacterial potential. Some of those demonstrated excellent antioxidant activity, and one product was identified as a promising antimicrobial candidate.
Keywords
About the authors
M. Irshad
Department of Chemistry, Division of Science and Technology
Author for correspondence.
Email: misbahchatha@hotmail.com
Pakistan, Lahore, 54770
Q. Ali
Department of Chemistry, Division of Science and Technology
Email: misbahchatha@hotmail.com
Pakistan, Lahore, 54770
F. Iram
Department of Chemistry
Email: misbahchatha@hotmail.com
Pakistan, Lahore, 75500
S. A. Ahamad
Department of Chemistry
Email: misbahchatha@hotmail.com
Pakistan, Lahore, 75500
M. Saleem
Department of Chemistry
Email: misbahchatha@hotmail.com
Pakistan, Dera Ghazi Khan, 32200
M. Saadia
Department of Biochemistry
Email: misbahchatha@hotmail.com
Pakistan, Sargodha, 40100
M. Batool
Department of Chemistry
Email: misbahchatha@hotmail.com
Pakistan, Lahore, 54590
A. Kanwal
Department of Chemistry, Division of Science and Technology
Email: misbahchatha@hotmail.com
Pakistan, Lahore, 54770
S. Tabassum
Department of Chemistry, Division of Science and Technology
Email: misbahchatha@hotmail.com
Pakistan, Lahore, 54770