5-Amino-Substituted Derivatives of 4-Nitrofurazane: Synthesis, Structure, and Biological Activity
- Autores: Galkina I.1, Takhautdinova G.1, Ivshin K.1, Khayarov K.1, Islamov D.1, Bakhtiyarova Y.1, Yamalieva L.1, Kataeva O.1, Galkin V.1
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Afiliações:
- Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
- Edição: Volume 88, Nº 5 (2018)
- Páginas: 898-902
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222177
- DOI: https://doi.org/10.1134/S1070363218050092
- ID: 222177
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Resumo
New amination reactions of 5-chloro-4-nitrobenzofurazane with different amines were studied. The reactions of 5-chloro-4-nitrobenzofurazane with 2,4,6-trichloro-, para-acetyl-, and para-carboxyethylanilines gave the products of aromatic nucleophilic substitution of the chlorine substituent in the nitrogenous heterocycle, the composition and structure of which was established by chemical, physical, and physicochemical methods and X-ray diffraction analysis. The thermal stability was studied by synchronous thermogravimetry and differential scanning calorimetry (TG‒DSC). The synthesized compounds showed a high antibacterial and antimycotic activity against human and animal pathogenic microflora.
Sobre autores
I. Galkina
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Autor responsável pela correspondência
Email: vig54@mail.ru
Rússia, Kazan, Tatarstan, 420008
G. Takhautdinova
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Rússia, Kazan, Tatarstan, 420008
K. Ivshin
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Rússia, Kazan, Tatarstan, 420008
Kh. Khayarov
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Rússia, Kazan, Tatarstan, 420008
D. Islamov
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Rússia, Kazan, Tatarstan, 420008
Yu. Bakhtiyarova
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Rússia, Kazan, Tatarstan, 420008
L. Yamalieva
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Rússia, Kazan, Tatarstan, 420008
O. Kataeva
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Rússia, Kazan, Tatarstan, 420008
V. Galkin
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Rússia, Kazan, Tatarstan, 420008