5-Amino-Substituted Derivatives of 4-Nitrofurazane: Synthesis, Structure, and Biological Activity
- Authors: Galkina I.V.1, Takhautdinova G.L.1, Ivshin K.A.1, Khayarov K.R.1, Islamov D.R.1, Bakhtiyarova Y.V.1, Yamalieva L.N.1, Kataeva O.N.1, Galkin V.I.1
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Affiliations:
- Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
- Issue: Vol 88, No 5 (2018)
- Pages: 898-902
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222177
- DOI: https://doi.org/10.1134/S1070363218050092
- ID: 222177
Cite item
Abstract
New amination reactions of 5-chloro-4-nitrobenzofurazane with different amines were studied. The reactions of 5-chloro-4-nitrobenzofurazane with 2,4,6-trichloro-, para-acetyl-, and para-carboxyethylanilines gave the products of aromatic nucleophilic substitution of the chlorine substituent in the nitrogenous heterocycle, the composition and structure of which was established by chemical, physical, and physicochemical methods and X-ray diffraction analysis. The thermal stability was studied by synchronous thermogravimetry and differential scanning calorimetry (TG‒DSC). The synthesized compounds showed a high antibacterial and antimycotic activity against human and animal pathogenic microflora.
About the authors
I. V. Galkina
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Author for correspondence.
Email: vig54@mail.ru
Russian Federation, Kazan, Tatarstan, 420008
G. L. Takhautdinova
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Russian Federation, Kazan, Tatarstan, 420008
K. A. Ivshin
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Russian Federation, Kazan, Tatarstan, 420008
Kh. R. Khayarov
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Russian Federation, Kazan, Tatarstan, 420008
D. R. Islamov
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Russian Federation, Kazan, Tatarstan, 420008
Yu. V. Bakhtiyarova
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Russian Federation, Kazan, Tatarstan, 420008
L. N. Yamalieva
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Russian Federation, Kazan, Tatarstan, 420008
O. N. Kataeva
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Russian Federation, Kazan, Tatarstan, 420008
V. I. Galkin
Kazan (Volga Region) Federal University, ul. Kremlevskaya 18
Email: vig54@mail.ru
Russian Federation, Kazan, Tatarstan, 420008