An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones and Their Antimicrobial Activity
- Autores: Sakram B.1, Ravi D.1, Ashok K.1, Rambabu S.1, Sonyanaik B.1, Kurumanna A.1
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Afiliações:
- Department of Chemistry
- Edição: Volume 88, Nº 4 (2018)
- Páginas: 780-788
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222148
- DOI: https://doi.org/10.1134/S1070363218040242
- ID: 222148
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Resumo
The Buchwald–Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd(PPh3)4 and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones. Structures of the synthesized compounds were evaluated by IR, 1H and 13C NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus.
Sobre autores
B. Sakram
Department of Chemistry
Autor responsável pela correspondência
Email: bschemou@gmail.com
Índia, Hyderabad, 500007
D. Ravi
Department of Chemistry
Email: bschemou@gmail.com
Índia, Hyderabad, 500007
K. Ashok
Department of Chemistry
Email: bschemou@gmail.com
Índia, Hyderabad, 500007
S. Rambabu
Department of Chemistry
Email: bschemou@gmail.com
Índia, Hyderabad, 500007
B. Sonyanaik
Department of Chemistry
Email: bschemou@gmail.com
Índia, Hyderabad, 500007
A. Kurumanna
Department of Chemistry
Email: bschemou@gmail.com
Índia, Hyderabad, 500007