An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones and Their Antimicrobial Activity
- 作者: Sakram B.1, Ravi D.1, Ashok K.1, Rambabu S.1, Sonyanaik B.1, Kurumanna A.1
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隶属关系:
- Department of Chemistry
- 期: 卷 88, 编号 4 (2018)
- 页面: 780-788
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222148
- DOI: https://doi.org/10.1134/S1070363218040242
- ID: 222148
如何引用文章
详细
The Buchwald–Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd(PPh3)4 and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones. Structures of the synthesized compounds were evaluated by IR, 1H and 13C NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus.
作者简介
B. Sakram
Department of Chemistry
编辑信件的主要联系方式.
Email: bschemou@gmail.com
印度, Hyderabad, 500007
D. Ravi
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, 500007
K. Ashok
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, 500007
S. Rambabu
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, 500007
B. Sonyanaik
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, 500007
A. Kurumanna
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, 500007