An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones and Their Antimicrobial Activity
- Authors: Sakram B.1, Ravi D.1, Ashok K.1, Rambabu S.1, Sonyanaik B.1, Kurumanna A.1
-
Affiliations:
- Department of Chemistry
- Issue: Vol 88, No 4 (2018)
- Pages: 780-788
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222148
- DOI: https://doi.org/10.1134/S1070363218040242
- ID: 222148
Cite item
Abstract
The Buchwald–Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd(PPh3)4 and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones. Structures of the synthesized compounds were evaluated by IR, 1H and 13C NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus.
About the authors
B. Sakram
Department of Chemistry
Author for correspondence.
Email: bschemou@gmail.com
India, Hyderabad, 500007
D. Ravi
Department of Chemistry
Email: bschemou@gmail.com
India, Hyderabad, 500007
K. Ashok
Department of Chemistry
Email: bschemou@gmail.com
India, Hyderabad, 500007
S. Rambabu
Department of Chemistry
Email: bschemou@gmail.com
India, Hyderabad, 500007
B. Sonyanaik
Department of Chemistry
Email: bschemou@gmail.com
India, Hyderabad, 500007
A. Kurumanna
Department of Chemistry
Email: bschemou@gmail.com
India, Hyderabad, 500007