Synthesis and antimicrobial screening of novel 9-{2-[(1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives
- Autores: Jalapathi P.1, Kishore Kumar A.1, Sunitha V.1, Shankar B.1, Murali Krishna T.2, Lincoln C.2
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Afiliações:
- Department of Chemistry
- Department of Biotechnology
- Edição: Volume 87, Nº 9 (2017)
- Páginas: 2011-2020
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221237
- DOI: https://doi.org/10.1134/S1070363217090171
- ID: 221237
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Resumo
A series of novel 9-{2-[(1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives were synthesized by a click chemistry approach. The structures of all the newly synthesized compounds were characterized by IR, MASS, 1H and 13C NMR spectral data. The final analogues showed good to excellent antibacterial and antifungal activities in an agar well diffusion assay. Compounds 6i and 6f were the most active against all the test bacterial and fungal strains.
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Sobre autores
P. Jalapathi
Department of Chemistry
Autor responsável pela correspondência
Email: pochampalli.ou.chemi@gmail.com
Índia, Saifabad, Hyderabad, Telangana, 500004
A. Kishore Kumar
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
Índia, Saifabad, Hyderabad, Telangana, 500004
V. Sunitha
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
Índia, Saifabad, Hyderabad, Telangana, 500004
B. Shankar
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
Índia, Saifabad, Hyderabad, Telangana, 500004
T. Murali Krishna
Department of Biotechnology
Email: pochampalli.ou.chemi@gmail.com
Índia, Kishanpura, Hanamkonda, Warangal, Telangana, 506001
Ch. Lincoln
Department of Biotechnology
Email: pochampalli.ou.chemi@gmail.com
Índia, Kishanpura, Hanamkonda, Warangal, Telangana, 506001