Synthesis and antimicrobial screening of novel 9-{2-[(1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives
- Authors: Jalapathi P.1, Kishore Kumar A.1, Sunitha V.1, Shankar B.1, Murali Krishna T.2, Lincoln C.A.2
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Affiliations:
- Department of Chemistry
- Department of Biotechnology
- Issue: Vol 87, No 9 (2017)
- Pages: 2011-2020
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221237
- DOI: https://doi.org/10.1134/S1070363217090171
- ID: 221237
Cite item
Abstract
A series of novel 9-{2-[(1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives were synthesized by a click chemistry approach. The structures of all the newly synthesized compounds were characterized by IR, MASS, 1H and 13C NMR spectral data. The final analogues showed good to excellent antibacterial and antifungal activities in an agar well diffusion assay. Compounds 6i and 6f were the most active against all the test bacterial and fungal strains.
About the authors
P. Jalapathi
Department of Chemistry
Author for correspondence.
Email: pochampalli.ou.chemi@gmail.com
India, Saifabad, Hyderabad, Telangana, 500004
A. Kishore Kumar
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
India, Saifabad, Hyderabad, Telangana, 500004
V. Sunitha
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
India, Saifabad, Hyderabad, Telangana, 500004
B. Shankar
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
India, Saifabad, Hyderabad, Telangana, 500004
T. Murali Krishna
Department of Biotechnology
Email: pochampalli.ou.chemi@gmail.com
India, Kishanpura, Hanamkonda, Warangal, Telangana, 506001
Ch. Abraham Lincoln
Department of Biotechnology
Email: pochampalli.ou.chemi@gmail.com
India, Kishanpura, Hanamkonda, Warangal, Telangana, 506001
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