Green synthesis and antibacterial evaluation of some new 1-aryl-3-(1-aryl-1H-[1,2,3]triazol-4-yl)-propenones
- Autores: Linga Goud G.1, Ramesh S.1, Ashok D.1, Prabhakar Reddy V.1
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Afiliações:
- Green and Medicinal Chemistry Lab, Department of Chemistry
- Edição: Volume 86, Nº 6 (2016)
- Páginas: 1419-1423
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215437
- DOI: https://doi.org/10.1134/S1070363216060293
- ID: 215437
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Resumo
A new series of 1-aryl-3-(1-aryl-1H-[1,2,3]triazol-4-yl)propenones (6a–6j) was synthesized by condensation of substituted acetophenones (5a–5c) with substituted 1-aryl-1H-[1,2,3]triazole-4-carbaldehydes (4a–4d) in the presence of potassium hydroxide under conditions of grinding and microwave irradiation. All the newly synthesized compounds were characterized by the IR, NMR, and mass spectroscopic analyses and their antibacterial activity against gram-positive and gram-negative bacterial strains was evaluated. Among the compounds synthesized, better activity was exhibited by 6a, 6c, 6f, 6g, and 6i.
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Sobre autores
G. Linga Goud
Green and Medicinal Chemistry Lab, Department of Chemistry
Autor responsável pela correspondência
Email: lingamgudikadi@gmail.com
Índia, Hyderabad, 500007
S. Ramesh
Green and Medicinal Chemistry Lab, Department of Chemistry
Email: lingamgudikadi@gmail.com
Índia, Hyderabad, 500007
D. Ashok
Green and Medicinal Chemistry Lab, Department of Chemistry
Email: lingamgudikadi@gmail.com
Índia, Hyderabad, 500007
V. Prabhakar Reddy
Green and Medicinal Chemistry Lab, Department of Chemistry
Email: lingamgudikadi@gmail.com
Índia, Hyderabad, 500007