Synthesis and Anticancer Activity of Amide Derivatives of 1,2-Isoxazole Combined 1,2,4-Thiadiazole
- Авторлар: Shahinshavali S.1, Sreenivasulu R.2, Guttikonda V.1, Kolli D.1, Rao M.1
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Мекемелер:
- Department of Chemistry
- Department of Chemistry, University College of Engineering (Autonomous)
- Шығарылым: Том 89, № 2 (2019)
- Беттер: 324-329
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222765
- DOI: https://doi.org/10.1134/S1070363219020257
- ID: 222765
Дәйексөз келтіру
Аннотация
A series of amide derivatives of 1,2-isoxazole combined with 1,2,4-thiadiazole are synthesized 11a–11j. Their chemical structures are confirmed by 1H and 13C NMR, and mass spectra. The products are tested for their anticancer activity against four types of human cancer cell lines, including MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian). Etoposide is used as a positive control. Most of the compounds show good anticancer activity. The compounds 11b, 11c, 11d, 11e, 11g, and 11j demonstrate more potent activity than etoposide.
Негізгі сөздер
Авторлар туралы
S. Shahinshavali
Department of Chemistry
Email: professormandava@gmail.com
Үндістан, Machilipatnam, Andhra Pradesh, 521001
R. Sreenivasulu
Department of Chemistry, University College of Engineering (Autonomous)
Email: professormandava@gmail.com
Үндістан, Kakinada, Andhra Pradesh, 533003
V. Guttikonda
Department of Chemistry
Email: professormandava@gmail.com
Үндістан, Vijayawad, Andhra Pradesh, 520004
D. Kolli
Department of Chemistry
Email: professormandava@gmail.com
Үндістан, Vaddeswaram, Andhra Pradesh, 522502
M. Rao
Department of Chemistry
Хат алмасуға жауапты Автор.
Email: professormandava@gmail.com
Үндістан, Machilipatnam, Andhra Pradesh, 521001