Synthesis and Anticancer Activity of Amide Derivatives of 1,2-Isoxazole Combined 1,2,4-Thiadiazole
- Authors: Shahinshavali S.1, Sreenivasulu R.2, Guttikonda V.R.1, Kolli D.1, Rao M.V.1
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Affiliations:
- Department of Chemistry
- Department of Chemistry, University College of Engineering (Autonomous)
- Issue: Vol 89, No 2 (2019)
- Pages: 324-329
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222765
- DOI: https://doi.org/10.1134/S1070363219020257
- ID: 222765
Cite item
Abstract
A series of amide derivatives of 1,2-isoxazole combined with 1,2,4-thiadiazole are synthesized 11a–11j. Their chemical structures are confirmed by 1H and 13C NMR, and mass spectra. The products are tested for their anticancer activity against four types of human cancer cell lines, including MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian). Etoposide is used as a positive control. Most of the compounds show good anticancer activity. The compounds 11b, 11c, 11d, 11e, 11g, and 11j demonstrate more potent activity than etoposide.
Keywords
About the authors
S. Shahinshavali
Department of Chemistry
Email: professormandava@gmail.com
India, Machilipatnam, Andhra Pradesh, 521001
R. Sreenivasulu
Department of Chemistry, University College of Engineering (Autonomous)
Email: professormandava@gmail.com
India, Kakinada, Andhra Pradesh, 533003
V. R. Guttikonda
Department of Chemistry
Email: professormandava@gmail.com
India, Vijayawad, Andhra Pradesh, 520004
D. Kolli
Department of Chemistry
Email: professormandava@gmail.com
India, Vaddeswaram, Andhra Pradesh, 522502
M. V. B. Rao
Department of Chemistry
Author for correspondence.
Email: professormandava@gmail.com
India, Machilipatnam, Andhra Pradesh, 521001