Synthesis and Anticancer Activity of Amide Derivatives of 1,2-Isoxazole Combined 1,2,4-Thiadiazole
- 作者: Shahinshavali S.1, Sreenivasulu R.2, Guttikonda V.1, Kolli D.1, Rao M.1
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隶属关系:
- Department of Chemistry
- Department of Chemistry, University College of Engineering (Autonomous)
- 期: 卷 89, 编号 2 (2019)
- 页面: 324-329
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222765
- DOI: https://doi.org/10.1134/S1070363219020257
- ID: 222765
如何引用文章
详细
A series of amide derivatives of 1,2-isoxazole combined with 1,2,4-thiadiazole are synthesized 11a–11j. Their chemical structures are confirmed by 1H and 13C NMR, and mass spectra. The products are tested for their anticancer activity against four types of human cancer cell lines, including MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian). Etoposide is used as a positive control. Most of the compounds show good anticancer activity. The compounds 11b, 11c, 11d, 11e, 11g, and 11j demonstrate more potent activity than etoposide.
作者简介
S. Shahinshavali
Department of Chemistry
Email: professormandava@gmail.com
印度, Machilipatnam, Andhra Pradesh, 521001
R. Sreenivasulu
Department of Chemistry, University College of Engineering (Autonomous)
Email: professormandava@gmail.com
印度, Kakinada, Andhra Pradesh, 533003
V. Guttikonda
Department of Chemistry
Email: professormandava@gmail.com
印度, Vijayawad, Andhra Pradesh, 520004
D. Kolli
Department of Chemistry
Email: professormandava@gmail.com
印度, Vaddeswaram, Andhra Pradesh, 522502
M. Rao
Department of Chemistry
编辑信件的主要联系方式.
Email: professormandava@gmail.com
印度, Machilipatnam, Andhra Pradesh, 521001