Synthesis and Biological Activity of 4-Aryl-N-(5,6-R-benzo[d]thiazol-2-yl)- 2-hydroxy-4-oxobut-2-enamides
- Авторлар: Pulina N.1, Lipatnikov K.1, Sobin F.1, Makhmudov R.2, Dubrovina S.1
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Мекемелер:
- Perm State Pharmaceutical Academy
- Perm State National Research University
- Шығарылым: Том 88, № 8 (2018)
- Беттер: 1618-1622
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222359
- DOI: https://doi.org/10.1134/S107036321808011X
- ID: 222359
Дәйексөз келтіру
Аннотация
The interaction of 5-arylfuran-2,3-diones with 5,6-R-benzo[d]thiazole-2-amines has resulted in 4-aryl-N-(5,6-R-benzo[d]thiazol-2-yl)-2-hydroxy-4-oxobut-2-enamides. The products structure has been confirmed by means of IR, NMR, and 1H NMR spectroscopy as well as mass spectrometry. Analgesic and antimicrobial activities of the prepared compounds have been studied; acute toxicity of the most active compounds has been determined. The relationship between the structure and biological activity of the obtained compounds has been elucidated. The compounds acting comparably or better than the reference drugs have been found.
Авторлар туралы
N. Pulina
Perm State Pharmaceutical Academy
Email: lkv2901@mail.ru
Ресей, ul. Polevaya 2, Perm, 614990
K. Lipatnikov
Perm State Pharmaceutical Academy
Хат алмасуға жауапты Автор.
Email: lkv2901@mail.ru
Ресей, ul. Polevaya 2, Perm, 614990
F. Sobin
Perm State Pharmaceutical Academy
Email: lkv2901@mail.ru
Ресей, ul. Polevaya 2, Perm, 614990
R. Makhmudov
Perm State National Research University
Email: lkv2901@mail.ru
Ресей, Perm
S. Dubrovina
Perm State Pharmaceutical Academy
Email: lkv2901@mail.ru
Ресей, ul. Polevaya 2, Perm, 614990