Synthesis and Biological Activity of 4-Aryl-N-(5,6-R-benzo[d]thiazol-2-yl)- 2-hydroxy-4-oxobut-2-enamides
- Autores: Pulina N.1, Lipatnikov K.1, Sobin F.1, Makhmudov R.2, Dubrovina S.1
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Afiliações:
- Perm State Pharmaceutical Academy
- Perm State National Research University
- Edição: Volume 88, Nº 8 (2018)
- Páginas: 1618-1622
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222359
- DOI: https://doi.org/10.1134/S107036321808011X
- ID: 222359
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Resumo
The interaction of 5-arylfuran-2,3-diones with 5,6-R-benzo[d]thiazole-2-amines has resulted in 4-aryl-N-(5,6-R-benzo[d]thiazol-2-yl)-2-hydroxy-4-oxobut-2-enamides. The products structure has been confirmed by means of IR, NMR, and 1H NMR spectroscopy as well as mass spectrometry. Analgesic and antimicrobial activities of the prepared compounds have been studied; acute toxicity of the most active compounds has been determined. The relationship between the structure and biological activity of the obtained compounds has been elucidated. The compounds acting comparably or better than the reference drugs have been found.
Sobre autores
N. Pulina
Perm State Pharmaceutical Academy
Email: lkv2901@mail.ru
Rússia, ul. Polevaya 2, Perm, 614990
K. Lipatnikov
Perm State Pharmaceutical Academy
Autor responsável pela correspondência
Email: lkv2901@mail.ru
Rússia, ul. Polevaya 2, Perm, 614990
F. Sobin
Perm State Pharmaceutical Academy
Email: lkv2901@mail.ru
Rússia, ul. Polevaya 2, Perm, 614990
R. Makhmudov
Perm State National Research University
Email: lkv2901@mail.ru
Rússia, Perm
S. Dubrovina
Perm State Pharmaceutical Academy
Email: lkv2901@mail.ru
Rússia, ul. Polevaya 2, Perm, 614990