Synthesis and Biological Activity of 4-Aryl-N-(5,6-R-benzo[d]thiazol-2-yl)- 2-hydroxy-4-oxobut-2-enamides
- 作者: Pulina N.A.1, Lipatnikov K.V.1, Sobin F.V.1, Makhmudov R.R.2, Dubrovina S.S.1
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隶属关系:
- Perm State Pharmaceutical Academy
- Perm State National Research University
- 期: 卷 88, 编号 8 (2018)
- 页面: 1618-1622
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222359
- DOI: https://doi.org/10.1134/S107036321808011X
- ID: 222359
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详细
The interaction of 5-arylfuran-2,3-diones with 5,6-R-benzo[d]thiazole-2-amines has resulted in 4-aryl-N-(5,6-R-benzo[d]thiazol-2-yl)-2-hydroxy-4-oxobut-2-enamides. The products structure has been confirmed by means of IR, NMR, and 1H NMR spectroscopy as well as mass spectrometry. Analgesic and antimicrobial activities of the prepared compounds have been studied; acute toxicity of the most active compounds has been determined. The relationship between the structure and biological activity of the obtained compounds has been elucidated. The compounds acting comparably or better than the reference drugs have been found.
作者简介
N. Pulina
Perm State Pharmaceutical Academy
Email: lkv2901@mail.ru
俄罗斯联邦, ul. Polevaya 2, Perm, 614990
K. Lipatnikov
Perm State Pharmaceutical Academy
编辑信件的主要联系方式.
Email: lkv2901@mail.ru
俄罗斯联邦, ul. Polevaya 2, Perm, 614990
F. Sobin
Perm State Pharmaceutical Academy
Email: lkv2901@mail.ru
俄罗斯联邦, ul. Polevaya 2, Perm, 614990
R. Makhmudov
Perm State National Research University
Email: lkv2901@mail.ru
俄罗斯联邦, Perm
S. Dubrovina
Perm State Pharmaceutical Academy
Email: lkv2901@mail.ru
俄罗斯联邦, ul. Polevaya 2, Perm, 614990
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