Synthesis and Biological Activity of 4-Aryl-N-(5,6-R-benzo[d]thiazol-2-yl)- 2-hydroxy-4-oxobut-2-enamides
- Authors: Pulina N.A.1, Lipatnikov K.V.1, Sobin F.V.1, Makhmudov R.R.2, Dubrovina S.S.1
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Affiliations:
- Perm State Pharmaceutical Academy
- Perm State National Research University
- Issue: Vol 88, No 8 (2018)
- Pages: 1618-1622
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222359
- DOI: https://doi.org/10.1134/S107036321808011X
- ID: 222359
Cite item
Abstract
The interaction of 5-arylfuran-2,3-diones with 5,6-R-benzo[d]thiazole-2-amines has resulted in 4-aryl-N-(5,6-R-benzo[d]thiazol-2-yl)-2-hydroxy-4-oxobut-2-enamides. The products structure has been confirmed by means of IR, NMR, and 1H NMR spectroscopy as well as mass spectrometry. Analgesic and antimicrobial activities of the prepared compounds have been studied; acute toxicity of the most active compounds has been determined. The relationship between the structure and biological activity of the obtained compounds has been elucidated. The compounds acting comparably or better than the reference drugs have been found.
About the authors
N. A. Pulina
Perm State Pharmaceutical Academy
Email: lkv2901@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
K. V. Lipatnikov
Perm State Pharmaceutical Academy
Author for correspondence.
Email: lkv2901@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
F. V. Sobin
Perm State Pharmaceutical Academy
Email: lkv2901@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
R. R. Makhmudov
Perm State National Research University
Email: lkv2901@mail.ru
Russian Federation, Perm
S. S. Dubrovina
Perm State Pharmaceutical Academy
Email: lkv2901@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
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