Synthesis and Biological Activity of 4-Aryl-N-(5,6-R-benzo[d]thiazol-2-yl)- 2-hydroxy-4-oxobut-2-enamides


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

The interaction of 5-arylfuran-2,3-diones with 5,6-R-benzo[d]thiazole-2-amines has resulted in 4-aryl-N-(5,6-R-benzo[d]thiazol-2-yl)-2-hydroxy-4-oxobut-2-enamides. The products structure has been confirmed by means of IR, NMR, and 1H NMR spectroscopy as well as mass spectrometry. Analgesic and antimicrobial activities of the prepared compounds have been studied; acute toxicity of the most active compounds has been determined. The relationship between the structure and biological activity of the obtained compounds has been elucidated. The compounds acting comparably or better than the reference drugs have been found.

作者简介

N. Pulina

Perm State Pharmaceutical Academy

Email: lkv2901@mail.ru
俄罗斯联邦, ul. Polevaya 2, Perm, 614990

K. Lipatnikov

Perm State Pharmaceutical Academy

编辑信件的主要联系方式.
Email: lkv2901@mail.ru
俄罗斯联邦, ul. Polevaya 2, Perm, 614990

F. Sobin

Perm State Pharmaceutical Academy

Email: lkv2901@mail.ru
俄罗斯联邦, ul. Polevaya 2, Perm, 614990

R. Makhmudov

Perm State National Research University

Email: lkv2901@mail.ru
俄罗斯联邦, Perm

S. Dubrovina

Perm State Pharmaceutical Academy

Email: lkv2901@mail.ru
俄罗斯联邦, ul. Polevaya 2, Perm, 614990

补充文件

附件文件
动作
1. JATS XML

版权所有 © Pleiades Publishing, Ltd., 2018