Green Synthesis and Biological Evaluation of Novel Fused 6-(2-Chloro-4-fluorophenyl)-9-arylimidazo[1,2-a][1,8]naphthyridine Derivatives Catalyzed by DABCO
- Авторлар: Sonyanaik B.1, Sakram B.1, Shyam P.2, Madhu P.2, Govan M.1
-
Мекемелер:
- Department of Chemistry
- Biomedical Informatics Center
- Шығарылым: Том 88, № 7 (2018)
- Беттер: 1495-1501
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222331
- DOI: https://doi.org/10.1134/S107036321807023X
- ID: 222331
Дәйексөз келтіру
Аннотация
An efficient synthesis of 6-(2-chloro-4-fluorophenyl)-9-phenylimidazo[1,2-a][1,8]naphthyridine derivatives by the reaction of phenacyl bromide with substituted heterocyclic amines in the presence of DABCO catalyst is described. Solid state conditions of the process accelerate accumulation of the targeted products with high yields and exclude formation of side-products. Antibacterial and fungal activities tests of all newly synthesized products demonstrate their pronounced potency, which is the highest for compounds 5c–5e. Molecular docking studies support well with the antimicrobial activity data accumulated for the products.
Негізгі сөздер
Авторлар туралы
B. Sonyanaik
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Hyderabad, Telangana, 500007
B. Sakram
Department of Chemistry
Хат алмасуға жауапты Автор.
Email: bschemou@gmail.com
Үндістан, Hyderabad, Telangana, 500007
P. Shyam
Biomedical Informatics Center
Email: bschemou@gmail.com
Үндістан, Hyderabad, 50007
P. Madhu
Biomedical Informatics Center
Email: bschemou@gmail.com
Үндістан, Hyderabad, 50007
M. Govan
Department of Chemistry
Email: bschemou@gmail.com
Үндістан, Hyderabad, Telangana, 500007