Green Synthesis and Biological Evaluation of Novel Fused 6-(2-Chloro-4-fluorophenyl)-9-arylimidazo[1,2-a][1,8]naphthyridine Derivatives Catalyzed by DABCO
- Authors: Sonyanaik B.1, Sakram B.1, Shyam P.2, Madhu P.2, Govan M.1
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Affiliations:
- Department of Chemistry
- Biomedical Informatics Center
- Issue: Vol 88, No 7 (2018)
- Pages: 1495-1501
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222331
- DOI: https://doi.org/10.1134/S107036321807023X
- ID: 222331
Cite item
Abstract
An efficient synthesis of 6-(2-chloro-4-fluorophenyl)-9-phenylimidazo[1,2-a][1,8]naphthyridine derivatives by the reaction of phenacyl bromide with substituted heterocyclic amines in the presence of DABCO catalyst is described. Solid state conditions of the process accelerate accumulation of the targeted products with high yields and exclude formation of side-products. Antibacterial and fungal activities tests of all newly synthesized products demonstrate their pronounced potency, which is the highest for compounds 5c–5e. Molecular docking studies support well with the antimicrobial activity data accumulated for the products.
About the authors
B. Sonyanaik
Department of Chemistry
Email: bschemou@gmail.com
India, Hyderabad, Telangana, 500007
B. Sakram
Department of Chemistry
Author for correspondence.
Email: bschemou@gmail.com
India, Hyderabad, Telangana, 500007
P. Shyam
Biomedical Informatics Center
Email: bschemou@gmail.com
India, Hyderabad, 50007
P. Madhu
Biomedical Informatics Center
Email: bschemou@gmail.com
India, Hyderabad, 50007
M. Govan
Department of Chemistry
Email: bschemou@gmail.com
India, Hyderabad, Telangana, 500007