Green Synthesis and Biological Evaluation of Novel Fused 6-(2-Chloro-4-fluorophenyl)-9-arylimidazo[1,2-a][1,8]naphthyridine Derivatives Catalyzed by DABCO
- 作者: Sonyanaik B.1, Sakram B.1, Shyam P.2, Madhu P.2, Govan M.1
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隶属关系:
- Department of Chemistry
- Biomedical Informatics Center
- 期: 卷 88, 编号 7 (2018)
- 页面: 1495-1501
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222331
- DOI: https://doi.org/10.1134/S107036321807023X
- ID: 222331
如何引用文章
详细
An efficient synthesis of 6-(2-chloro-4-fluorophenyl)-9-phenylimidazo[1,2-a][1,8]naphthyridine derivatives by the reaction of phenacyl bromide with substituted heterocyclic amines in the presence of DABCO catalyst is described. Solid state conditions of the process accelerate accumulation of the targeted products with high yields and exclude formation of side-products. Antibacterial and fungal activities tests of all newly synthesized products demonstrate their pronounced potency, which is the highest for compounds 5c–5e. Molecular docking studies support well with the antimicrobial activity data accumulated for the products.
作者简介
B. Sonyanaik
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, Telangana, 500007
B. Sakram
Department of Chemistry
编辑信件的主要联系方式.
Email: bschemou@gmail.com
印度, Hyderabad, Telangana, 500007
P. Shyam
Biomedical Informatics Center
Email: bschemou@gmail.com
印度, Hyderabad, 50007
P. Madhu
Biomedical Informatics Center
Email: bschemou@gmail.com
印度, Hyderabad, 50007
M. Govan
Department of Chemistry
Email: bschemou@gmail.com
印度, Hyderabad, Telangana, 500007