Synthesis and Biological Activity of β-Aminoketones, Secondary Aminopropanols and Oximes of 2-Aminothiophene Series
- Authors: Gevorgyan G.A.1, Hakobyan N.Z.1, Hovakimyan S.S.1, Melkonyan A.G.1, Panosyan G.A.1
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Affiliations:
- Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- Issue: Vol 89, No 11 (2019)
- Pages: 2328-2332
- Section: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/223182
- DOI: https://doi.org/10.1134/S1070363219110264
- ID: 223182
Cite item
Abstract
The reactions of substituted 3-dietliylaminopropan-1-ones hydrochlorides with 2-amino-6-(H, alkyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitriles and ethyl 2-amino-6-(H, methyl)-4,5,6,7-tetrariydrobenzo[b]-thiophene-3-carboxylate furnished β-aminoketones of 2-aminothiophene series. The latter were converted into the corresponding secondary aminopropanols and oximes. Antioxidant activity of synthesized compounds and effect on some parameters of the blood coagulation system were investigated.
About the authors
G. A. Gevorgyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Author for correspondence.
Email: gyulgev@gmail.com
Armenia, Yerevan, 0014
N. Z. Hakobyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: gyulgev@gmail.com
Armenia, Yerevan, 0014
S. S. Hovakimyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: gyulgev@gmail.com
Armenia, Yerevan, 0014
A. G. Melkonyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: gyulgev@gmail.com
Armenia, Yerevan, 0014
G. A. Panosyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: gyulgev@gmail.com
Armenia, Yerevan, 0014
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