Synthesis of N-vinylpyrrolidone copolymers with 2-aminoethyl methacrylate as drug carriers
- Authors: Solovskii M.V.1, Borisenko M.S.1, Ershov A.Y.1, Zakharova N.V.1, Tarabukina E.B.1
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Affiliations:
- Institute of Macromolecular Compounds
- Issue: Vol 87, No 2 (2017)
- Pages: 276-281
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/218344
- DOI: https://doi.org/10.1134/S1070363217020207
- ID: 218344
Cite item
Abstract
Radical copolymerization of N-vinylpyrrolidone and 2-aminoethyl methacrylate hydrochloride has been studied. Molecular and hydrodynamic characteristics of the resulting copolymers have been determined, and their structure has been confirmed. Conditions favoring conversion of these copolymers into copolymers of N-vinylpyrrolidone with 2-aminoethyl methacrylate of different composition have been elucidated. The suitability of the prepared copolymers as polymeric carriers of monofluoroquinolone ofloxacin has been demonstrated.
About the authors
M. V. Solovskii
Institute of Macromolecular Compounds
Email: aarghm@yandex.ru
Russian Federation, Bol’shoi pr. 31, St. Petersburg, 199004
M. S. Borisenko
Institute of Macromolecular Compounds
Author for correspondence.
Email: aarghm@yandex.ru
Russian Federation, Bol’shoi pr. 31, St. Petersburg, 199004
A. Yu. Ershov
Institute of Macromolecular Compounds
Email: aarghm@yandex.ru
Russian Federation, Bol’shoi pr. 31, St. Petersburg, 199004
N. V. Zakharova
Institute of Macromolecular Compounds
Email: aarghm@yandex.ru
Russian Federation, Bol’shoi pr. 31, St. Petersburg, 199004
E. B. Tarabukina
Institute of Macromolecular Compounds
Email: aarghm@yandex.ru
Russian Federation, Bol’shoi pr. 31, St. Petersburg, 199004