Synthesis, Characterization, and Anti-Diabetic Therapeutic Activity of New Vanadyl(II) Complexes with Orotic Acid and Different Amino Acids Mixed Ligands
- Authors: Al-Wasidi A.S.1, Al-Jafshar N.M.1, Al-Anazi A.M.1, Refat M.S.2,3, Ismail L.A.3, Al-Omar M.A.4, Naglah A.M.4,5, Kalmouch A.5
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Affiliations:
- Department of Chemistry, College of Science
- Chemistry Department, Faculty of Science
- Department of Chemistry, Faculty of Science
- Department of Pharmaceutical Chemistry, Drug Exploration and Development Chair (DEDC), College of Pharmacy
- Peptide Chemistry Department, Chemical Industries Research Division
- Issue: Vol 89, No 10 (2019)
- Pages: 2121-2128
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223128
- DOI: https://doi.org/10.1134/S1070363219100219
- ID: 223128
Cite item
Abstract
Mixed ligand vanadyl(II) complexes of orotic acid and six different amino acids (isoleucine, threonine, proline, phenylalanine, lysine, and glutamine) have been synthesized. Vanadyl(II) orotate mixed ligand complexes are studied on the basis of conductivity, FTIR, UV-Vis, TG-DTG-DTA, magnetic moments, solid powder XRD, SEM, and TEM measurements. These non-electrolyte complexes are of 1 : 1 : 1 stochiometry. The major goal of this article is design and synthesis of new insulin alternative anti-diabetic drug. The insulin hormone and blood glucose level, lipid profile, liver and kidney functions, and superoxide dismutase antioxidant (SOD) are the factors to identify efficiency of the new synthesized compounds as antidiabetic drug agents.
Keywords
About the authors
A. S. Al-Wasidi
Department of Chemistry, College of Science
Email: msrefat@yahoo.com
Saudi Arabia, Riyadh, 11671
N. M. Al-Jafshar
Department of Chemistry, College of Science
Email: msrefat@yahoo.com
Saudi Arabia, Riyadh, 11671
A. M. Al-Anazi
Department of Chemistry, College of Science
Email: msrefat@yahoo.com
Saudi Arabia, Riyadh, 11671
M. S. Refat
Chemistry Department, Faculty of Science; Department of Chemistry, Faculty of Science
Author for correspondence.
Email: msrefat@yahoo.com
Saudi Arabia, Al-Hawiah, Taif, 21974; Port Said
L. A. Ismail
Department of Chemistry, Faculty of Science
Email: msrefat@yahoo.com
Egypt, Port Said
M. A. Al-Omar
Department of Pharmaceutical Chemistry, Drug Exploration and Development Chair (DEDC), College of Pharmacy
Email: msrefat@yahoo.com
Saudi Arabia, Riyadh, 11451
A. M. Naglah
Department of Pharmaceutical Chemistry, Drug Exploration and Development Chair (DEDC), College of Pharmacy; Peptide Chemistry Department, Chemical Industries Research Division
Email: msrefat@yahoo.com
Saudi Arabia, Riyadh, 11451; Dokki, Cairo, 12622
Atef Kalmouch
Peptide Chemistry Department, Chemical Industries Research Division
Email: msrefat@yahoo.com
Egypt, Dokki, Cairo, 12622
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