Synthesis, Characterization, and Anti-Diabetic Therapeutic Activity of New Vanadyl(II) Complexes with Orotic Acid and Different Amino Acids Mixed Ligands
- Авторы: Al-Wasidi A.1, Al-Jafshar N.1, Al-Anazi A.1, Refat M.2,3, Ismail L.3, Al-Omar M.4, Naglah A.4,5, Kalmouch A.5
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Учреждения:
- Department of Chemistry, College of Science
- Chemistry Department, Faculty of Science
- Department of Chemistry, Faculty of Science
- Department of Pharmaceutical Chemistry, Drug Exploration and Development Chair (DEDC), College of Pharmacy
- Peptide Chemistry Department, Chemical Industries Research Division
- Выпуск: Том 89, № 10 (2019)
- Страницы: 2121-2128
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223128
- DOI: https://doi.org/10.1134/S1070363219100219
- ID: 223128
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Аннотация
Mixed ligand vanadyl(II) complexes of orotic acid and six different amino acids (isoleucine, threonine, proline, phenylalanine, lysine, and glutamine) have been synthesized. Vanadyl(II) orotate mixed ligand complexes are studied on the basis of conductivity, FTIR, UV-Vis, TG-DTG-DTA, magnetic moments, solid powder XRD, SEM, and TEM measurements. These non-electrolyte complexes are of 1 : 1 : 1 stochiometry. The major goal of this article is design and synthesis of new insulin alternative anti-diabetic drug. The insulin hormone and blood glucose level, lipid profile, liver and kidney functions, and superoxide dismutase antioxidant (SOD) are the factors to identify efficiency of the new synthesized compounds as antidiabetic drug agents.
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Об авторах
A. Al-Wasidi
Department of Chemistry, College of Science
Email: msrefat@yahoo.com
Саудовская Аравия, Riyadh, 11671
N. Al-Jafshar
Department of Chemistry, College of Science
Email: msrefat@yahoo.com
Саудовская Аравия, Riyadh, 11671
A. Al-Anazi
Department of Chemistry, College of Science
Email: msrefat@yahoo.com
Саудовская Аравия, Riyadh, 11671
M. Refat
Chemistry Department, Faculty of Science; Department of Chemistry, Faculty of Science
Автор, ответственный за переписку.
Email: msrefat@yahoo.com
Саудовская Аравия, Al-Hawiah, Taif, 21974; Port Said
L. Ismail
Department of Chemistry, Faculty of Science
Email: msrefat@yahoo.com
Египет, Port Said
M. Al-Omar
Department of Pharmaceutical Chemistry, Drug Exploration and Development Chair (DEDC), College of Pharmacy
Email: msrefat@yahoo.com
Саудовская Аравия, Riyadh, 11451
A. Naglah
Department of Pharmaceutical Chemistry, Drug Exploration and Development Chair (DEDC), College of Pharmacy; Peptide Chemistry Department, Chemical Industries Research Division
Email: msrefat@yahoo.com
Саудовская Аравия, Riyadh, 11451; Dokki, Cairo, 12622
Atef Kalmouch
Peptide Chemistry Department, Chemical Industries Research Division
Email: msrefat@yahoo.com
Египет, Dokki, Cairo, 12622
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