Email this article Synthesis, Structure, and Biological Activity of Cinnamoyl-Containing Cytisine and Anabasine Alkaloids Derivatives
- Authors: Nurkenov O.A.1, Nurmaganbetov Z.S.1,2, Seilkhanov T.M.3, Fazylov S.D.1, Satpayeva Z.B.1, Turdybekov K.M.4, Talipov S.A.5, Seydakhmetova R.B.6
-
Affiliations:
- Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan
- Karaganda State Medical University
- Sh. Ualikhanov Kokshetau State University
- E.A. Buketov Karaganda State University
- A.S. Sadykov Institute of Bioorganic Chemistry
- International Research and Production Holding “Phytochemistry”
- Issue: Vol 89, No 10 (2019)
- Pages: 2044-2051
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223112
- DOI: https://doi.org/10.1134/S1070363219100098
- ID: 223112
Cite item
Open Access
Access granted
Subscription Access
Abstract
The reactions of the cytisine and anabasine alkaloids with cinnamic acid chloride have been studied, and hydrazinolysis of the resulting N-cinnamoylcytisine and N-cinnamoylanabazine has been carried out. The reaction of cinnamoyl isothiocyanate with alkaloids has afforded the corresponding thiourea derivatives. Antimicrobial and cytotoxic activity of cinnamoyl-containing derivatives of these alkaloids has been evaluated.
About the authors
O. A. Nurkenov
Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan
Author for correspondence.
Email: nurkenov_oral@mail.ru
Kazakhstan, ul. Alikhanova 1, Karaganda, 100008
Zh. S. Nurmaganbetov
Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan; Karaganda State Medical University
Email: nurkenov_oral@mail.ru
Kazakhstan, ul. Alikhanova 1, Karaganda, 100008; Karaganda
T. M. Seilkhanov
Sh. Ualikhanov Kokshetau State University
Email: nurkenov_oral@mail.ru
Kazakhstan, Kokshetau
S. D. Fazylov
Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan
Email: nurkenov_oral@mail.ru
Kazakhstan, ul. Alikhanova 1, Karaganda, 100008
Zh. B. Satpayeva
Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan
Email: nurkenov_oral@mail.ru
Kazakhstan, ul. Alikhanova 1, Karaganda, 100008
K. M. Turdybekov
E.A. Buketov Karaganda State University
Email: nurkenov_oral@mail.ru
Kazakhstan, Karaganda
S. A. Talipov
A.S. Sadykov Institute of Bioorganic Chemistry
Email: nurkenov_oral@mail.ru
Uzbekistan, Tashkent
R. B. Seydakhmetova
International Research and Production Holding “Phytochemistry”
Email: nurkenov_oral@mail.ru
Kazakhstan, Karaganda
