Email this article Synthesis and Antibacterial Assay of Some New Pyrenyl Pyridine Candidates
- Authors: Khalifa N.M.1,2, Haiba M.E.2, Taha M.M.3, Al-Omar M.A.1
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Affiliations:
- Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy
- Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Division
- Department of Chemistry, Faculty of Science
- Issue: Vol 89, No 2 (2019)
- Pages: 319-323
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222764
- DOI: https://doi.org/10.1134/S1070363219020245
- ID: 222764
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Abstract
Novel polycyclic compounds, 1-pyrene-based pyridone derivatives, are synthesized by treatment of pyrenyl acetohydtazide with several arylidenemalononitriles and acetylacetone. Intramolecular cyclization furnishes the functionalized substituted pyridine-2-ones with high yields. Structures of the products are elucidated from the spectral data. Tests on antibacterial activity of the products reveal their high antibacterial effect.
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About the authors
N. M. Khalifa
Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy; Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Division
Author for correspondence.
Email: nkhalifa.c@ksu.edu.sa
Saudi Arabia, Riyadh, 11451; Giza
M. E. Haiba
Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Division
Email: nkhalifa.c@ksu.edu.sa
Egypt, Giza
M. M. Taha
Department of Chemistry, Faculty of Science
Email: nkhalifa.c@ksu.edu.sa
Egypt, Menoufia
M. A. Al-Omar
Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy
Email: nkhalifa.c@ksu.edu.sa
Saudi Arabia, Riyadh, 11451
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