Email this article α-Azidoalkylphosphonate in 1,3-Dipolar Cycloaddition with Propargyl-Containing Pharmacophores
- Authors: Sokolov V.B.1, Aksinenko A.Y.1, Epishina T.A.1, Goreva T.V.1
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Affiliations:
- Institute of Physiologically Active Compounds of the Russian Academy of Sciences
- Issue: Vol 89, No 1 (2019)
- Pages: 160-164
- Section: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/222730
- DOI: https://doi.org/10.1134/S1070363219010304
- ID: 222730
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Abstract
Copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition reactions of α-azidoalkylphosphonates with propargyl-containing pharmacophores such as phenothiazine, tetrahydro-γ-carboline, tetrahydrocarbazole, carbazole and 3,5-dimethyl-1-aminoadamantanes led to the formation of the corresponding 1, 4-substituted 1,2,3-triazoles and make it possible to introduce a diethoxyphosphorylalkyl fragment into the molecules of potential neuroprotectors using a triazole-containing spacer.
About the authors
V. B. Sokolov
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Author for correspondence.
Email: alaks@ipac.ac.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, 142432
A. Yu. Aksinenko
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, 142432
T. A. Epishina
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, 142432
T. V. Goreva
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, 142432
