Enviar artigo por via de e-mail α-Azidoalkylphosphonate in 1,3-Dipolar Cycloaddition with Propargyl-Containing Pharmacophores
- Autores: Sokolov V.1, Aksinenko A.1, Epishina T.1, Goreva T.1
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Afiliações:
- Institute of Physiologically Active Compounds of the Russian Academy of Sciences
- Edição: Volume 89, Nº 1 (2019)
- Páginas: 160-164
- Seção: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/222730
- DOI: https://doi.org/10.1134/S1070363219010304
- ID: 222730
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Resumo
Copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition reactions of α-azidoalkylphosphonates with propargyl-containing pharmacophores such as phenothiazine, tetrahydro-γ-carboline, tetrahydrocarbazole, carbazole and 3,5-dimethyl-1-aminoadamantanes led to the formation of the corresponding 1, 4-substituted 1,2,3-triazoles and make it possible to introduce a diethoxyphosphorylalkyl fragment into the molecules of potential neuroprotectors using a triazole-containing spacer.
Sobre autores
V. Sokolov
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: alaks@ipac.ac.ru
Rússia, Severnyi proezd 1, Chernogolovka, 142432
A. Aksinenko
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Rússia, Severnyi proezd 1, Chernogolovka, 142432
T. Epishina
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Rússia, Severnyi proezd 1, Chernogolovka, 142432
T. Goreva
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Rússia, Severnyi proezd 1, Chernogolovka, 142432
