α-Azidoalkylphosphonate in 1,3-Dipolar Cycloaddition with Propargyl-Containing Pharmacophores
- 作者: Sokolov V.1, Aksinenko A.1, Epishina T.1, Goreva T.1
-
隶属关系:
- Institute of Physiologically Active Compounds of the Russian Academy of Sciences
- 期: 卷 89, 编号 1 (2019)
- 页面: 160-164
- 栏目: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/222730
- DOI: https://doi.org/10.1134/S1070363219010304
- ID: 222730
如何引用文章
详细
Copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition reactions of α-azidoalkylphosphonates with propargyl-containing pharmacophores such as phenothiazine, tetrahydro-γ-carboline, tetrahydrocarbazole, carbazole and 3,5-dimethyl-1-aminoadamantanes led to the formation of the corresponding 1, 4-substituted 1,2,3-triazoles and make it possible to introduce a diethoxyphosphorylalkyl fragment into the molecules of potential neuroprotectors using a triazole-containing spacer.
作者简介
V. Sokolov
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: alaks@ipac.ac.ru
俄罗斯联邦, Severnyi proezd 1, Chernogolovka, 142432
A. Aksinenko
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Email: alaks@ipac.ac.ru
俄罗斯联邦, Severnyi proezd 1, Chernogolovka, 142432
T. Epishina
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Email: alaks@ipac.ac.ru
俄罗斯联邦, Severnyi proezd 1, Chernogolovka, 142432
T. Goreva
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Email: alaks@ipac.ac.ru
俄罗斯联邦, Severnyi proezd 1, Chernogolovka, 142432
![](/img/style/loading.gif)