Synthesis and Antitubercular, Antimicrobial, and Hemolytic Activity of Methyl D-Glucopyranuronate and Its Simplest Derivatives

M. G. Belenok; O. V. Andreeva; B. F. Garifullin; A. S. Strobykina; M. A. Kravchenko; A. D. Voloshina; V. E. Kataev

doi:10.1134/S1070363217120106

Synthesis and Antitubercular, Antimicrobial, and Hemolytic Activity of Methyl D-Glucopyranuronate and Its Simplest Derivatives

Authors: Belenok M.G.¹, Andreeva O.V.¹, Garifullin B.F.¹, Strobykina A.S.¹, Kravchenko M.A.², Voloshina A.D.¹, Kataev V.E.¹
Affiliations:
1. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
2. Ural Research Institute of Phthisiopulmonology
Issue: Vol 87, No 12 (2017)
Pages: 2816-2825
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/221690
DOI: https://doi.org/10.1134/S1070363217120106
ID: 221690

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Abstract

Methyl glucuronate and some of its simplest derivatives have been synthesized, and their antitubercular, antimicrobial, and hemolytic activities have been studied. The simplest derivatives of glucuronic acid have been shown for the first time to exhibit a high antitubercular activity which is comparable with the activity of isoniazid.