Synthesis and Antitubercular, Antimicrobial, and Hemolytic Activity of Methyl D-Glucopyranuronate and Its Simplest Derivatives
- Autores: Belenok M.1, Andreeva O.1, Garifullin B.1, Strobykina A.1, Kravchenko M.2, Voloshina A.1, Kataev V.1
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Afiliações:
- Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
- Ural Research Institute of Phthisiopulmonology
- Edição: Volume 87, Nº 12 (2017)
- Páginas: 2816-2825
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221690
- DOI: https://doi.org/10.1134/S1070363217120106
- ID: 221690
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Resumo
Methyl glucuronate and some of its simplest derivatives have been synthesized, and their antitubercular, antimicrobial, and hemolytic activities have been studied. The simplest derivatives of glucuronic acid have been shown for the first time to exhibit a high antitubercular activity which is comparable with the activity of isoniazid.
Sobre autores
M. Belenok
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: kataev@iopc.ru
Rússia, ul. Arbuzova 8, Kazan, Tatarstan, 420088
O. Andreeva
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: kataev@iopc.ru
Rússia, ul. Arbuzova 8, Kazan, Tatarstan, 420088
B. Garifullin
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: kataev@iopc.ru
Rússia, ul. Arbuzova 8, Kazan, Tatarstan, 420088
A. Strobykina
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: kataev@iopc.ru
Rússia, ul. Arbuzova 8, Kazan, Tatarstan, 420088
M. Kravchenko
Ural Research Institute of Phthisiopulmonology
Email: kataev@iopc.ru
Rússia, ul. 22 Parts”ezda 50, Yekaterinburg, 620039
A. Voloshina
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Email: kataev@iopc.ru
Rússia, ul. Arbuzova 8, Kazan, Tatarstan, 420088
V. Kataev
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Autor responsável pela correspondência
Email: kataev@iopc.ru
Rússia, ul. Arbuzova 8, Kazan, Tatarstan, 420088