Synthesis and Biological Activity of 3,4-Diaryl-5-[4-(acetylsulfamoyl)phenyl]-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-ones and Their Sodium Salts
- Authors: Bobrovskaya O.V.1, Gein V.L.1, Seliverstov G.V.1, Chashchina S.V.1, Dmitriev M.V.2
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Affiliations:
- Perm State Pharmaceutical Academy
- Perm State National Research University
- Issue: Vol 87, No 12 (2017)
- Pages: 2776-2782
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221677
- DOI: https://doi.org/10.1134/S1070363217120040
- ID: 221677
Cite item
Abstract
3,4-Diaryl-5-[4-(acetylsulfamoyl)phenyl]-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-ones were synthesized be reaction of 5-aryl-4-aroyl-1-[4-(acetylsulfamoyl)phenyl]-3-hydroxy-1H-pyrrole-2(5H)-ones with hydrazine hydrate in glacial acetic acid, and their sodium salts were obtained by treatment with sodium methoxide in methanol–DMF (1: 1). Analgesic and anti-inflammatory activity and acute toxicity of the synthesized compounds were studied.
About the authors
O. V. Bobrovskaya
Perm State Pharmaceutical Academy
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
V. L. Gein
Perm State Pharmaceutical Academy
Author for correspondence.
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
G. V. Seliverstov
Perm State Pharmaceutical Academy
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
S. V. Chashchina
Perm State Pharmaceutical Academy
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
M. V. Dmitriev
Perm State National Research University
Email: geinvl48@mail.ru
Russian Federation, ul. Bukireva 15, Perm, 614990