Synthesis and Biological Activity of 3,4-Diaryl-5-[4-(acetylsulfamoyl)phenyl]-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-ones and Their Sodium Salts
- Autores: Bobrovskaya O.1, Gein V.1, Seliverstov G.1, Chashchina S.1, Dmitriev M.2
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Afiliações:
- Perm State Pharmaceutical Academy
- Perm State National Research University
- Edição: Volume 87, Nº 12 (2017)
- Páginas: 2776-2782
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221677
- DOI: https://doi.org/10.1134/S1070363217120040
- ID: 221677
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Resumo
3,4-Diaryl-5-[4-(acetylsulfamoyl)phenyl]-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-ones were synthesized be reaction of 5-aryl-4-aroyl-1-[4-(acetylsulfamoyl)phenyl]-3-hydroxy-1H-pyrrole-2(5H)-ones with hydrazine hydrate in glacial acetic acid, and their sodium salts were obtained by treatment with sodium methoxide in methanol–DMF (1: 1). Analgesic and anti-inflammatory activity and acute toxicity of the synthesized compounds were studied.
Sobre autores
O. Bobrovskaya
Perm State Pharmaceutical Academy
Email: geinvl48@mail.ru
Rússia, ul. Polevaya 2, Perm, 614990
V. Gein
Perm State Pharmaceutical Academy
Autor responsável pela correspondência
Email: geinvl48@mail.ru
Rússia, ul. Polevaya 2, Perm, 614990
G. Seliverstov
Perm State Pharmaceutical Academy
Email: geinvl48@mail.ru
Rússia, ul. Polevaya 2, Perm, 614990
S. Chashchina
Perm State Pharmaceutical Academy
Email: geinvl48@mail.ru
Rússia, ul. Polevaya 2, Perm, 614990
M. Dmitriev
Perm State National Research University
Email: geinvl48@mail.ru
Rússia, ul. Bukireva 15, Perm, 614990