Synthesis and Biological Activity of 3,4-Diaryl-5-[4-(acetylsulfamoyl)phenyl]-4,5-dihydropyrrolo[3,4- c ]pyrazol-6(2 H )-ones and Their Sodium Salts

O. V. Bobrovskaya; V. L. Gein; G. V. Seliverstov; S. V. Chashchina; M. V. Dmitriev

doi:10.1134/S1070363217120040

Synthesis and Biological Activity of 3,4-Diaryl-5-[4-(acetylsulfamoyl)phenyl]-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-ones and Their Sodium Salts

作者: Bobrovskaya O.¹, Gein V.¹, Seliverstov G.¹, Chashchina S.¹, Dmitriev M.²
隶属关系:
1. Perm State Pharmaceutical Academy
2. Perm State National Research University
期: 卷 87, 编号 12 (2017)
页面: 2776-2782
栏目: Article
URL: https://journals.rcsi.science/1070-3632/article/view/221677
DOI: https://doi.org/10.1134/S1070363217120040
ID: 221677

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3,4-Diaryl-5-[4-(acetylsulfamoyl)phenyl]-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-ones were synthesized be reaction of 5-aryl-4-aroyl-1-[4-(acetylsulfamoyl)phenyl]-3-hydroxy-1H-pyrrole-2(5H)-ones with hydrazine hydrate in glacial acetic acid, and their sodium salts were obtained by treatment with sodium methoxide in methanol–DMF (1: 1). Analgesic and anti-inflammatory activity and acute toxicity of the synthesized compounds were studied.