Biological evaluations and spectroscopic characterizations of 3-(4-ethoxyphenyl)-2-methylacrylate based organotin(IV) carboxylates derivatives
- Authors: Tariq M.1,2, Sirajuddin M.2, Ali S.2, Khalid N.3, Shah N.A.4
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Affiliations:
- Institute of Chemical Sciences
- Department of Chemistry
- Chemistry Division
- Department of Biosciences
- Issue: Vol 87, No 11 (2017)
- Pages: 2690-2698
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221626
- DOI: https://doi.org/10.1134/S1070363217110263
- ID: 221626
Cite item
Abstract
Six new organotin(IV) carboxylates, [Me2SnL2] (1), [n-Bu2SnL2] (2), [n-Oct2SnL2] (3), [Me3SnL] (4), [n-Bu3SnL] (5) and [Ph3SnL] (6), where L = 3-(4-ethoxyphenyl)-2-methylacrylate, have been synthesized and characterized by FT-IR, NMR spectroscopy and elemental analyses. The synthesized compounds were tested for in vitro antibacterial and antifungal activities. The complexes 4–6 demonstrated higher activity than the complexes 1–3. UV-Vis absorption spectroscopy indicated that the ligand and its complexes interacted with DNA via partial intercalation as well as minor groove binding.
About the authors
M. Tariq
Institute of Chemical Sciences; Department of Chemistry
Author for correspondence.
Email: mtnazir@yahoo.com
Pakistan, Multan, 60000; Islamabad, 45320
M. Sirajuddin
Department of Chemistry
Email: mtnazir@yahoo.com
Pakistan, Bannu, 28100
S. Ali
Department of Chemistry
Email: mtnazir@yahoo.com
Pakistan, Islamabad, 45320
N. Khalid
Chemistry Division
Email: mtnazir@yahoo.com
Pakistan, Islamabad
N. A. Shah
Department of Biosciences
Email: mtnazir@yahoo.com
Pakistan, Islamabad