Email this article Reaction of diphenylphosphinoylallene derivatives of cytisine
- Authors: Brel’ V.K.1, Kovaleva E.Y.1, Enchev D.D.2
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Affiliations:
- Nesmeyanov Institute of Organoelement Compounds
- Konstantin Preslavsky University of Shumen
- Issue: Vol 87, No 8 (2017)
- Pages: 1731-1736
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/220988
- DOI: https://doi.org/10.1134/S1070363217080163
- ID: 220988
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Abstract
Diphenylphosphinoylallenes containing a ClCH2 group were synthesized, and their reaction with cytisine was studied. It was shown that the reaction involves exclusives as nucleophilic substitution of chlorine in the chloromethyl group. The synthesized conjugates of cytisine with diphenylphosphinoylallene derivatives are of interest as potential agonists of nicotinic acetylcholine neuroreceptors (nAChRs).
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About the authors
V. K. Brel’
Nesmeyanov Institute of Organoelement Compounds
Author for correspondence.
Email: v_brel@mail.ru
Russian Federation, ul. Vavilova 28, Moscow, 119991
E. Yu. Kovaleva
Nesmeyanov Institute of Organoelement Compounds
Email: v_brel@mail.ru
Russian Federation, ul. Vavilova 28, Moscow, 119991
D. D. Enchev
Konstantin Preslavsky University of Shumen
Email: v_brel@mail.ru
Bulgaria, Shumen
