Synthesis of some substituted 5H-furo[3,2-g]chromene and benzofuran sulfonate derivatives as potent anti-HIV agents
- Авторы: Amr A.1,2, Abdalla M.3, Essaouy S.4, Areef M.4, Elgamal M.2, Nassear T.4, Haschich A.4, Al-Omar M.1
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Учреждения:
- Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy
- Applied Organic Chemistry Department
- Research Unit
- Organic Chemistry Department, Faculty of Science
- Выпуск: Том 87, № 7 (2017)
- Страницы: 1591-1600
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/220816
- DOI: https://doi.org/10.1134/S1070363217070246
- ID: 220816
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Аннотация
Synthesized visnagin-9-sulfonyl esters underwent cleavage of their pyran ring upon treatment by hydroxylamine hydrochloride, hydrazine hydrate and primary amines. Reaction of visnagin-9-sulfonyl chloride 1 with alcohols or phenol gave the corresponding sulfonate derivatives 2, that were treated with hydroxylamine hydrochloride, anilines or hydrazine derivatives to give the corresponding compounds 3–5, respectively. The obtained products demonstrated potent anti-HIV activity.
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Об авторах
A. Amr
Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy; Applied Organic Chemistry Department
Email: mmostafa201120@yahoo.com
Саудовская Аравия, Riyadh, 11451; Dokki, Cairo, 12622
M. Abdalla
Research Unit
Автор, ответственный за переписку.
Email: mmostafa201120@yahoo.com
Египет, 6th October City
S. Essaouy
Organic Chemistry Department, Faculty of Science
Email: mmostafa201120@yahoo.com
Египет, Banha
M. Areef
Organic Chemistry Department, Faculty of Science
Email: mmostafa201120@yahoo.com
Египет, Banha
M. Elgamal
Applied Organic Chemistry Department
Email: mmostafa201120@yahoo.com
Египет, Dokki, Cairo, 12622
T. Nassear
Organic Chemistry Department, Faculty of Science
Email: mmostafa201120@yahoo.com
Египет, Banha
A. Haschich
Organic Chemistry Department, Faculty of Science
Email: mmostafa201120@yahoo.com
Египет, Banha
M. Al-Omar
Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy
Email: mmostafa201120@yahoo.com
Саудовская Аравия, Riyadh, 11451
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