Synthesis of some substituted 5 H -furo[3,2- g ]chromene and benzofuran sulfonate derivatives as potent anti-HIV agents

A. E. Amr; M. M. Abdalla; S. A. Essaouy; M. M. H. Areef; M. H. Elgamal; T. A. Nassear; A. E. Haschich; M. A. Al-Omar

doi:10.1134/S1070363217070246

Synthesis of some substituted 5H-furo[3,2-g]chromene and benzofuran sulfonate derivatives as potent anti-HIV agents

作者: Amr A.¹^,2, Abdalla M.³, Essaouy S.⁴, Areef M.⁴, Elgamal M.², Nassear T.⁴, Haschich A.⁴, Al-Omar M.¹
隶属关系:
1. Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy
2. Applied Organic Chemistry Department
3. Research Unit
4. Organic Chemistry Department, Faculty of Science
期: 卷 87, 编号 7 (2017)
页面: 1591-1600
栏目: Article
URL: https://journals.rcsi.science/1070-3632/article/view/220816
DOI: https://doi.org/10.1134/S1070363217070246
ID: 220816

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Synthesized visnagin-9-sulfonyl esters underwent cleavage of their pyran ring upon treatment by hydroxylamine hydrochloride, hydrazine hydrate and primary amines. Reaction of visnagin-9-sulfonyl chloride 1 with alcohols or phenol gave the corresponding sulfonate derivatives 2, that were treated with hydroxylamine hydrochloride, anilines or hydrazine derivatives to give the corresponding compounds 3–5, respectively. The obtained products demonstrated potent anti-HIV activity.