Synthesis of some substituted 5H-furo[3,2-g]chromene and benzofuran sulfonate derivatives as potent anti-HIV agents
- Autores: Amr A.1,2, Abdalla M.3, Essaouy S.4, Areef M.4, Elgamal M.2, Nassear T.4, Haschich A.4, Al-Omar M.1
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Afiliações:
- Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy
- Applied Organic Chemistry Department
- Research Unit
- Organic Chemistry Department, Faculty of Science
- Edição: Volume 87, Nº 7 (2017)
- Páginas: 1591-1600
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/220816
- DOI: https://doi.org/10.1134/S1070363217070246
- ID: 220816
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Resumo
Synthesized visnagin-9-sulfonyl esters underwent cleavage of their pyran ring upon treatment by hydroxylamine hydrochloride, hydrazine hydrate and primary amines. Reaction of visnagin-9-sulfonyl chloride 1 with alcohols or phenol gave the corresponding sulfonate derivatives 2, that were treated with hydroxylamine hydrochloride, anilines or hydrazine derivatives to give the corresponding compounds 3–5, respectively. The obtained products demonstrated potent anti-HIV activity.
Palavras-chave
Sobre autores
A. Amr
Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy; Applied Organic Chemistry Department
Email: mmostafa201120@yahoo.com
Arábia Saudita, Riyadh, 11451; Dokki, Cairo, 12622
M. Abdalla
Research Unit
Autor responsável pela correspondência
Email: mmostafa201120@yahoo.com
Egito, 6th October City
S. Essaouy
Organic Chemistry Department, Faculty of Science
Email: mmostafa201120@yahoo.com
Egito, Banha
M. Areef
Organic Chemistry Department, Faculty of Science
Email: mmostafa201120@yahoo.com
Egito, Banha
M. Elgamal
Applied Organic Chemistry Department
Email: mmostafa201120@yahoo.com
Egito, Dokki, Cairo, 12622
T. Nassear
Organic Chemistry Department, Faculty of Science
Email: mmostafa201120@yahoo.com
Egito, Banha
A. Haschich
Organic Chemistry Department, Faculty of Science
Email: mmostafa201120@yahoo.com
Egito, Banha
M. Al-Omar
Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy
Email: mmostafa201120@yahoo.com
Arábia Saudita, Riyadh, 11451
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