Functionalization of 5-(4-alkoxybenzyl)-4-R-4 H -1,2,4-triazole-3-thiols. Synthesis of novel DNA methylation inhibitors

M. R. Hakobyan; T. R. Hovsepyan; L. E. Nersesyan; A. S. Agaronyan; I. S. Danielyan; R. V. Paronikyan; N. S. Minasyan

doi:10.1134/S1070363217050140

Functionalization of 5-(4-alkoxybenzyl)-4-R-4H-1,2,4-triazole-3-thiols. Synthesis of novel DNA methylation inhibitors

Authors: Hakobyan M.R.¹, Hovsepyan T.R.¹, Nersesyan L.E.¹, Agaronyan A.S.¹, Danielyan I.S.¹, Paronikyan R.V.¹, Minasyan N.S.²
Affiliations:
1. A.L. Mnjoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry
2. Molecular Structure Research Center, Scientific-Technological Center of Organic and Pharmaceutical Chemistry
Issue: Vol 87, No 5 (2017)
Pages: 973-978
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/219740
DOI: https://doi.org/10.1134/S1070363217050140
ID: 219740

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Abstract

Aminomethylation and cyanoethylation reactions of 5-(4-alkoxybenzyl)-4-methyl(phenyl, allyl)-4H-1,2,4-triazole-3-thiols have been investigated. According to NMR spectroscopy data, the reactions occur at the nitrogen atom Ν². The effect of the synthesized compounds on cancer DNA methylation has been evaluated.