Synthesis, characterization, biological activity, and DFT-reactivity assessment of Mn(II), Co(II), and Cu(II) complexes of a new N2O tridentate Schiff base

Abstract

Three new homoleptic Schiff base: metal(II) complexes, bis{2-[(pyridin-2-yl) methylene-amino] naphthoxometal(II)} [M(npa)₂], (M = Mn(II) (1), Co(II) (2), Cu(II) (3), npa is monoanion of 2-[(pyridin-2-yl)methyleneamino]naphthol), have been prepared and characterized by elemental analyses, FT–IR, ¹H and ¹³C NMR, and HR-MS-TOF. Antimicrobial activity of the title compounds was tested against six standart bacteria and two standart fungi isolates by microdilution broth assay with Alamar Blue Dye. Biological activity of the complexes has been estimated by using Fukui reactivity indices and frontier molecular orbitals in the framework of conceptual density functional theory.