Email this article Diastereotopic derivatives of chiral alkoxyisoindolinones
- Authors: Grigoreva T.A.1, Garabadzhiu A.V.1, Tribulovich V.G.1
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Affiliations:
- St. Petersburg State Institute of Technology (Technical University)
- Issue: Vol 86, No 11 (2016)
- Pages: 2454-2461
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/216503
- DOI: https://doi.org/10.1134/S1070363216110098
- ID: 216503
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Abstract
A method for synthesis of 2,3-substituted 3-hydroxyisoindolin-1-one acyl derivatives, modified reactivators of tumor suppressor protein p53, was developed; these compounds were synthesized and characterized. It was shown that diastereomeric esters of Boc-N-protected amino acids, unlike esters with a free amino group, can be preparatively isolated by flash chromatography using achiral media.
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About the authors
T. A. Grigoreva
St. Petersburg State Institute of Technology (Technical University)
Author for correspondence.
Email: rozentatiana@gmail.com
Russian Federation, Moskovskii pr. 26, St. Petersburg, 190013
A. V. Garabadzhiu
St. Petersburg State Institute of Technology (Technical University)
Email: rozentatiana@gmail.com
Russian Federation, Moskovskii pr. 26, St. Petersburg, 190013
V. G. Tribulovich
St. Petersburg State Institute of Technology (Technical University)
Email: rozentatiana@gmail.com
Russian Federation, Moskovskii pr. 26, St. Petersburg, 190013
